منابع مشابه
Common fold in helix-hairpin-helix proteins.
Helix-hairpin-helix (HhH) is a widespread motif involved in non-sequence-specific DNA binding. The majority of HhH motifs function as DNA-binding modules, however, some of them are used to mediate protein-protein interactions or have acquired enzymatic activity by incorporating catalytic residues (DNA glycosylases). From sequence and structural analysis of HhH-containing proteins we conclude th...
متن کاملA common fold mediates vertebrate defense and bacterial attack.
Proteins containing membrane attack complex/perforin (MACPF) domains play important roles in vertebrate immunity, embryonic development, and neural-cell migration. In vertebrates, the ninth component of complement and perforin form oligomeric pores that lyse bacteria and kill virus-infected cells, respectively. However, the mechanism of MACPF function is unknown. We determined the crystal struc...
متن کاملA common toxin fold mediates microbial attack and plant defense.
Many plant pathogens secrete toxins that enhance microbial virulence by killing host cells. Usually, these toxins are produced by particular microbial taxa, such as bacteria or fungi. In contrast, many bacterial, fungal and oomycete species produce necrosis and ethylene-inducing peptide 1 (Nep1)-like proteins (NLPs) that trigger leaf necrosis and immunity-associated responses in various plants....
متن کاملCatching a Passing Moment:
This report describes a hitherto-isolated culture in northern Pakistan that has recently under gone rapid exposure to the outside world. Rapid change in Karimabad, a town of 4,600 peo ple in the Hunza Valley, has caused conflicts between cultural inertia and the forces of progress and modernization to surface and produced visible instances of cultural persistence and adap tation. For example...
متن کاملCatching a wave
Temporary circuits amplify spontaneous activity in the visual system of neonatal rats.
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ژورنال
عنوان ژورنال: Protein Science
سال: 1993
ISSN: 0961-8368,1469-896X
DOI: 10.1002/pro.5560020602